Premium
Synthesis of Some New 2‐(Phenoxyacetylthio)‐3‐aryl‐6‐bromo‐ or ‐6,8‐dibromoquinazoline‐4(3 H )‐ones a Possible AChE Inhibitors
Author(s) -
Hajela Km. Kanchan,
Sengupta Anil K.,
Shanker Kripa,
Doval Dinesh C.
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160509
Subject(s) - chemistry , aryl , aché , esterase , choline , in vitro , acetylcholinesterase , stereochemistry , enzyme , combinatorial chemistry , organic chemistry , biochemistry , alkyl
Sixteen new 2‐(phenoxyacetylthio)‐3‐aryl‐6‐bromo‐ or ‐6,8‐dibromoquinazolones were synthesized by condensation of various phenoxyacetyl chlorides with mercaptoquinazolones. Their inhibitory properties towards choline esterase and their bactericidal activities were studied in vitro. Nine of the compounds exhibited (>50%) choline esterase inhibition, whereas the antibacterial screening showed moderate results.