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Synthesis of Methylsilyl Derivates of Procaine and Their Diffusion Rates from an Ointment Base
Author(s) -
FemiOnadeko Bankole,
Komolafe Olusegun
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160406
Subject(s) - procaine , chemistry , trimethylsilyl , derivative (finance) , organic chemistry , base (topology) , hexafluorobenzene , vaseline , diffusion , benzene , nuclear chemistry , pharmacology , surgery , medicine , wound healing , financial economics , economics , mathematical analysis , physics , mathematics , thermodynamics
Four new methylsilyl and silicon compounds of procaine have been synthesised. Unlike procaine, the trimethylsilyl derivative was readily soluble in olive and vegetable oils at room temperature. The dimethylsilyl, methylsilyl and silicon derivatives were soluble in dioxane, carbon tetrachloride and benzene. The rates of diffusion of the four derivatives from an ointment base (lanoline, vaseline) into water were studied. The highest rate was exhibited by procaine and the lowest by its dimethylsilyl derivative. The LD 100 of the trimethylsilyl derivative when administered subcutaneously in olive oil to rats was 1.25 g/kg.