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Reactions with 3‐Pyrazolin‐5‐ones: Synthesis of some 4‐Substituted 2,3‐Dimethyl‐1‐phenyl‐3‐pyrazolin‐5‐ones
Author(s) -
ElSakka Ibrahim A.,
Kandil Adel,
ElMoghayar Mohamed H.
Publication year - 1983
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19833160115
Subject(s) - chemistry , hydrazine (antidepressant) , yield (engineering) , hydrate , furan , derivative (finance) , medicinal chemistry , chloroacetyl chloride , organic chemistry , materials science , chromatography , chloride , economics , financial economics , metallurgy
4‐Acetylantipyrine (1) was condensed with aromatic or heterocyclic aldehydes to yield the cinnamoylidene derivatives 4a—d. Compound 4b was converted into the pyrazolinylantipyrine derivative 9 by hydrazine hydrate. 4‐(Chloroacetyl)antipyrine (2) reacted with aldehydes to yield the furan‐2‐one derivatives 11 or the dihydroxy derivative 12. The behaviour of 4‐formylantipyrine toward methylenenitriles was investigated.