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Synthesis and Pharmacological Evaluation of New Ethyl Esters of N‐Acyl Amino Acids as CNS Agents
Author(s) -
Sathi Garima,
Gujrati Vibha R.,
Nath Chandishwar,
Agarwal Jagdish C.,
Bhargava Krishna P.,
Shanker Kripa
Publication year - 1982
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19823150707
Subject(s) - chemistry , monoamine oxidase , in vivo , in vitro , inhibitory postsynaptic potential , acute toxicity , ethyl ester , monoamine oxidase b , toxicity , amino acid , monoamine neurotransmitter , chemical synthesis , pharmacology , biochemistry , enzyme , organic chemistry , biology , serotonin , medicine , receptor , microbiology and biotechnology
The ethyl esters 1a‐1j and 2a‐2j of N ‐acyl amino acids were synthesized by the DCC method. The compounds were screened for their monoamine oxidase (MAO) inhibitory activity ( in vitro ) and various CNS activities ( in vivo ). Some compounds showed promising MAO inhibitory and anti‐depressant activities. The compounds did not produce acute neurological deficits and have low toxicity.