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Structure and Properties of Cyclic Polymethylene Ureas, III. Synthesis and Biological Activity of Some Mannich Bases of Tetrahydro‐2‐(1 H )‐Pyrimidinone
Author(s) -
Sidzhakova Dorothea,
Danchev Damian,
Galabov Angel S.,
Velichkova Emilia,
Karparov Alexander,
Chakova Nevena
Publication year - 1982
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19823150606
Subject(s) - chemistry , formaldehyde , mannich reaction , biological activity , stereochemistry , combinatorial chemistry , organic chemistry , in vitro , biochemistry , catalysis
Some N ‐mono‐ 2a–e and N,N ‐bis(aminomethyl) derivatives 3a–b of tetrahydro‐2‐(1 H )‐pyrimidinone 1a and tetrahydro‐2(1 H )‐pyrimidinethione 1e are obtained by the Mannich reaction of 1a or 1e with formaldehyde and secondary amines. The compounds show a marked antiviral activity.