Structure and Properties of Cyclic Polymethylene Ureas, III. Synthesis and Biological Activity of Some Mannich Bases of Tetrahydro‐2‐(1 H )‐Pyrimidinone | Zendy

Sidzhakova Dorothea | Zendy; Danchev Damian | Zendy; Galabov Angel S. | Zendy; Velichkova Emilia | Zendy; Karparov Alexander | Zendy; Chakova Nevena | Zendy

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Structure and Properties of Cyclic Polymethylene Ureas, III. Synthesis and Biological Activity of Some Mannich Bases of Tetrahydro‐2‐(1 H )‐Pyrimidinone

Author(s) -

Sidzhakova Dorothea,

Danchev Damian,

Galabov Angel S.,

Velichkova Emilia,

Karparov Alexander,

Chakova Nevena

Publication year - 1982

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19823150606

Subject(s) - chemistry , formaldehyde , mannich reaction , biological activity , stereochemistry , combinatorial chemistry , organic chemistry , in vitro , biochemistry , catalysis

Some N ‐mono‐ 2a–e and N,N ‐bis(aminomethyl) derivatives 3a–b of tetrahydro‐2‐(1 H )‐pyrimidinone 1a and tetrahydro‐2(1 H )‐pyrimidinethione 1e are obtained by the Mannich reaction of 1a or 1e with formaldehyde and secondary amines. The compounds show a marked antiviral activity.

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