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Potential Antitumor Agents, VII. 5‐Substituted 6‐Phenylimidazo[2,1‐ b ]thiazoles
Author(s) -
Andreani Aldo,
Bonazzi Daniela,
Rambaldi Mirella
Publication year - 1982
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19823150511
Subject(s) - chemistry , hydroxymethyl , stereochemistry , ring (chemistry) , acetic acid , combinatorial chemistry , chemical synthesis , organic chemistry , in vitro , biochemistry
Abstract The Vilsmeier reaction for the synthesis of the 5‐formylimidazo[2,1‐ b ]thiazoles 7–12 bearing a p ‐substituted phenyl ring in position 6 is reported. These compounds were used for the synthesis of the thiosemicarbazones 7a‐12a , tosylhydrazones 7b‐12b and 5‐hydroxymethyl derivatives 13–18 which, in turn, were used as starting materials for preparing the methylcarbamic 13a‐18a , ethylcarbamic 13b‐18b and acetic esters 13c‐18c . Preliminary results in the P‐388 leukemia test are reported.