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Indolyl Compounds as Antiinflammatory Agents
Author(s) -
Verma Mahima,
Gujrati Vibha R.,
Sharma Manju,
Saxena Anil K.,
Bhalla Triloki N.,
Sinha Jagdish N.,
Bhargava Krishna P.,
Shanker Kripa
Publication year - 1982
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19823150414
Subject(s) - phenylbutazone , chemistry , pharmacology , acetamide , acute toxicity , biological activity , toxicity , stereochemistry , biochemistry , medicine , organic chemistry , in vitro
Eight new ω‐(indol‐3‐yl)alkane carboxamides were synthesized and studied for their antiinflammatory activities against carrageenin induced paw oedema in albino rats. Six compounds exhibited various degrees of antiinflammatory activity, two compounds showed no activity. The most potent compound of the present series, 1‐(indol‐3‐yl)‐ N ‐{4‐[1‐(4‐methylphenyl)piperazinyl]phenyl}acetamide (7) as well as phenylbutazone showed dose dependent inhibition of rat paw oedema. The ulcerogenic activities of compound 7 and phenylbutazone were also dose dependent. However, 7 showed a much lower ulcerogenic activity. In view of its potent antiinflammatory activity, minimal ulcerogenic liability and low acute toxicity compound 7 appears promising.