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Synthesis and Antimicrobial Activity of Some New 5‐Nitrofuran Derivatives
Author(s) -
Roveri Paola,
Cavrini Vanni,
Gatti Rita,
Bianucci Fabrizio,
Legnani Paolo
Publication year - 1982
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19823150409
Subject(s) - nitrofuran , antimicrobial , nitro , chemistry , azide , in vitro , alkyl , stereochemistry , nitro compound , combinatorial chemistry , organic chemistry , biochemistry , biology , genetics
Starting from 5‐nitro‐2‐furoyl azide (1) , some new 5‐nitro‐2‐furamides 2a–d , O ‐alkyl N ‐(5‐nitro‐2‐furyl)carbamates 3a,b and 5‐nitro‐2‐ureidofurans 4a,b were synthesized and tested for in vitro antimicrobial activity. Compounds 2c and 2d exhibited appreciable activity against S. pyogenes and S. aureus.