Premium
Synthesis and CNS Activity of N,N ‐Disubstituted 1‐(Aminomethyl)‐5‐alkyl‐3‐(aryloxyacetylhydrazono)indolin‐2‐ones
Author(s) -
Agarwal Rajesh,
Misra Shobha,
Satsangi Rajiv K.,
Tiwari Shiva S.
Publication year - 1982
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19823150207
Subject(s) - isatin , chemistry , alkyl , mannich reaction , stereochemistry , biological activity , bicyclic molecule , chemical synthesis , medicinal chemistry , organic chemistry , in vitro , biochemistry , catalysis
Isatin and 5‐methylisatin were condensed with various aryloxyacetylhydrazides to furnish the 3‐(aryloxyacetylhydrazono)‐5‐alkylindolin‐2‐ones 1–4 . When 1–4 were subjected to Mannich reaction, the N,N ‐disubstituted 1‐(aminomethyl)‐5‐alkyl‐3‐(aryloxyacetylhydrazono)indolin‐2‐ones 5–8 were obtained. The compounds were CNS active and relatively non‐toxic (albino mice).