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Preparation of Carbamoyl Derivatives of Indole and of Derivatives of 1,2,4‐Triazol‐3‐one from Semicarbazides
Author(s) -
Butkiewicz Karol,
Wojciechowski Jan,
Pakula Ryszard
Publication year - 1982
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19823150116
Subject(s) - chemistry , indole test , levulinic acid , 1,2,4 triazole , organic chemistry , combinatorial chemistry , stereochemistry , catalysis
A simple and one‐step method for the preparation of the title compounds is described. Semicarbazides 2 react easily with levulinic acid in the presence of HCl to give 4 , whereas in a alkaline medium they cyclize to form the triazole derivatives 3 .