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Studies Aimed at the Synthesis of Morphine, IV: A New Approach to N ‐Norreticuline Derivatives from Homoveratronitrile
Author(s) -
Szántay Csaba,
Dörnyei Gábor,
Blaskó Gäbor,
BárczaiBeke Marietta,
Péchy Péter
Publication year - 1981
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19813141203
Subject(s) - demethylation , chemistry , halogen , lewis acids and bases , morphine , stereochemistry , organic chemistry , pharmacology , biochemistry , catalysis , biology , gene expression , alkyl , dna methylation , gene
Partial demethylation of homoveratronitrile (3a) with Lewis acids affords a mixture of the isomeric monophenols 3b and 3c . Separation of the isomers offers a new approach to N ‐norreticuline (1a) and its 6′‐halogen derivatives 1b,c .