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Synthesis of Potentially Antineoplastic Derivatives of N‐[ N ‐(2‐Chloroethyl)‐ N ‐nitrosocarbamoyl]amino Acids
Author(s) -
Tang WeiCi,
Eisenbrand Gerhard
Publication year - 1981
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19813141104
Subject(s) - chemistry , aniline , amino acid , azide , stereochemistry , aniline compounds , medicinal chemistry , organic chemistry , biochemistry
The synthesis of N ‐[ N ‐(2‐chloroethyl)‐ N ‐nitrosocarbamoyl]amino acids and their anilides, congeners of N ‐(2‐chloroethyl)‐ N ‐nitrosoureas, as potential antineoplastic substances is reported. N ‐[ N ‐(2‐chloroethyl)‐ N ‐nitrosocarbamoyl]amino acids are prepared by reaction of amino acids with N ‐(2‐chloroethyl)‐ N ‐nitrosocarbamoyl azide. Corresponding anilides and toluidides are obtained by condensation of the primary reaction products with aniline and toluidine using dicyclohexylcarbodiimide (DCC).