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Synthesis and Biological Properties of Some 3‐Heterocyclic Substituted Coumarins
Author(s) -
Kulkarni Manohar V.,
Patil Vemanna D.,
Biradar Vasant N.,
Nanjappa Siddaiah
Publication year - 1981
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19813140511
Subject(s) - coumarin , chemistry , antifungal , nitro , ring (chemistry) , biological activity , stereochemistry , antibacterial activity , combinatorial chemistry , organic chemistry , bacteria , in vitro , biochemistry , biology , microbiology and biotechnology , alkyl , genetics
2‐Mercaptobenzimidazoles and 3‐phenyl‐5‐mercapto‐ s ‐triazoles have been reacted with 3‐(bromoacetyl)coumarin to get the fused thiazoles. Antiinflammatory studies indicate that the introduction of a nitro group at the para position of the phenyl ring enhances the activity to a great extent. Antibacterial and antifungal activities were also tested.