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Potential Biologically Active Agents, XXVIII Synthesis of Substituted Indophenazines
Author(s) -
Varma Rajendra S.,
Pandey Rajnish K.
Publication year - 1981
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19813140405
Subject(s) - mannich reaction , chemistry , antibacterial activity , yield (engineering) , biological activity , organic chemistry , stereochemistry , bacteria , in vitro , catalysis , biochemistry , biology , materials science , metallurgy , genetics
5‐Fluoroisatin was condensed with various o ‐phenylenediamines to yield substituted 9‐fluoroindophenazines 1 . A similar reaction of 1‐methyl‐5‐fluoroisatin with o ‐phenylenediamines furnished 6‐methyl‐9‐fluoroindophenazines 2 . The Mannich reaction of 1 with secondary amines gave rise to substituted 6‐aminomethyl‐9‐fluorindophenazines 3 . Compounds 1 – 3 have been tested for their insecticidal and antibacterial activity.