Potential Biologically Active Agents, XXVIII Synthesis of Substituted Indophenazines | Zendy

Varma Rajendra S. | Zendy; Pandey Rajnish K. | Zendy

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Potential Biologically Active Agents, XXVIII Synthesis of Substituted Indophenazines

Author(s) -

Varma Rajendra S.,

Pandey Rajnish K.

Publication year - 1981

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19813140405

Subject(s) - mannich reaction , chemistry , antibacterial activity , yield (engineering) , biological activity , organic chemistry , stereochemistry , bacteria , in vitro , catalysis , biochemistry , biology , materials science , metallurgy , genetics

5‐Fluoroisatin was condensed with various o ‐phenylenediamines to yield substituted 9‐fluoroindophenazines 1 . A similar reaction of 1‐methyl‐5‐fluoroisatin with o ‐phenylenediamines furnished 6‐methyl‐9‐fluoroindophenazines 2 . The Mannich reaction of 1 with secondary amines gave rise to substituted 6‐aminomethyl‐9‐fluorindophenazines 3 . Compounds 1 – 3 have been tested for their insecticidal and antibacterial activity.

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