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Mass Spectral and Antimicrobial Studies of the Benzofuran Analog of Chloramphenicol
Author(s) -
Bevinakatti Hanamanthsa S.,
Badiger Virupax V.
Publication year - 1981
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19813140212
Subject(s) - chloramphenicol , benzofuran , chemistry , antimicrobial , diol , propane , antifungal , combinatorial chemistry , in vitro , ion , stereochemistry , antibiotics , organic chemistry , biochemistry , microbiology and biotechnology , biology
1‐(2‐Benzofuranyl)‐2‐(dichloroacetamido)propane‐1,3‐diol breaks down in a well‐defined manner upon electron impact. The principal ions formed are characterised and the most plausible mechanism of their formation is discussed. The results of in vitro antibacterial and antifungal screening of the benzofuran analog of chloramphenicol as well as its two precursors are reported.