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Research on Alkoxythiobenzamides, III: Synthesis of New 3,4,5‐Trimethoxythiobenzamides and Related Thiomorpholides with Potential Antisecretory and Antiulcer Activity
Author(s) -
Farina Carlo,
Pellegata Renato,
Pinza Mario,
Pifferi Giorgio
Publication year - 1981
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19813140204
Subject(s) - chemistry , acetic acid , organic chemistry , antiulcer drug , stereochemistry , pharmacology , medicine , drug
As a part of a project to synthesize new antisecretory and antiulcer alkoxythiobenzamides, 3,4,5‐trimethoxythiobenzamides 2 and 3 , which are analogues of trithiozine, were prepared by reaction of primary amines, acyclic secondary amines and various amino acids with methyl 3,4,5‐trimethoxydithiobenzoate ( 1a ) or (3,4,5‐trimethoxythiobenzoylthio)acetic acid ( 1b ). Some thiomorpholides 7 of alkoxyphenylalkanoic acids were prepared by thionation of the corresponding amides or from the appropriate ketones by the Willgerodt‐Kindler reaction.