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Potential Biologically Active Agents, XXVII: Synthesis of Some 4‐Substituted Phenylmercaptoacetic Acids
Author(s) -
Varma Rajendra S.,
Bahadur Surendra,
Agnihotri Anil K.
Publication year - 1981
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19813140202
Subject(s) - chemistry , quinazolinone , biological activity , mannich reaction , condensation , aryl , organic chemistry , condensation reaction , biochemistry , catalysis , in vitro , physics , alkyl , thermodynamics
Condensation of 4‐(3 H )‐quinazolinone (2) with 4‐(aminophenyl)‐mercaptoacetic acid under the conditions of the Mannich reaction furnished compounds 3a and 3b . Reaction of 4 with 4‐(amino‐phenyl)mercaptoacetic acid yielded 5 which when treated with aryl aldehydes gave 6 . Similarly, compounds 8 were obtained from 7 .
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