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Adrenergic Subsensitivity of a Cell‐free Adenylate Cyclase from Rat Brain after Chronic Imipramine Treatment
Author(s) -
Türck Michael,
Schocker Wilhelm F.,
Fathy Ahmed M.,
Schultz Joachim
Publication year - 1980
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19803130907
Subject(s) - imipramine , cyclase , adenylate kinase , endocrinology , medicine , phosphodiesterase , chemistry , adrenergic , phosphodiesterase inhibitor , enzyme , stimulation , receptor , biology , biochemistry , alternative medicine , pathology
A particulate adenylate cyclase was prepared from cerebral cortex of rats which had been chronically treated with imipramine. Noradrenaline stimulated adenylate cyclase activity was significantly reduced compared to untreated controls. Neither total phosphodiesterase activity nor basal and maximal adenylate cyclase activity were altered by the imipramine treatment. This indicates the development of adrenoceptor subsensitivity which is functionally retained in the cell‐free enzyme preparation.