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Mass Spectra of Amides of 2‐Amino‐2‐thiazoline
Author(s) -
Viallet MariePierre,
Ulrich Jacques,
Boucherle André
Publication year - 1980
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19803130611
Subject(s) - thiazoline , substituent , chemistry , tautomer , fragmentation (computing) , stereochemistry , molecule , ion , mass spectrum , polyatomic ion , organic chemistry , computer science , operating system
Five fragmentation patterns of the molecular ions of sixteen amides of 2‐amino‐2‐thiazoline and of one deuteriophenyl derivative are described: when R is a phenyl group substituted in ortho position by an R″ group, the [M‐R″] + ion is the main fragment, whereas in the other cases R″ = substituent in meta or para position it is the ion [M‐H] + . The amino⇄imino tautomerism of these molecular ions was studied. In addition, a correlation was found between the fragmentation patterns of the molecules and their pharmacological activities.