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Synthesis and Pharmacological Properties of Three Lidocaine Cyclovinylogues
Author(s) -
Valenti Piero,
Montanari Paola,
Da Re Paolo,
Soldani Giulio,
Bertelli Aldo
Publication year - 1980
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19803130314
Subject(s) - lidocaine , local anesthetic , chemistry , stereochemistry , ring (chemistry) , derivative (finance) , pharmacology , antiarrhythmic agent , benzene , topical anesthetic , chemical synthesis , anesthesia , organic chemistry , medicine , biochemistry , in vitro , heart disease , financial economics , economics
Three isomeric lidocaine cyclovinylogues in which a benzene ring is interposed between the carbamidic and diethylaminomethyl groups of the glycinamide chain, are described. The meta derivative possesses greater local anesthetic and antiarrhythmic activities than the parent compound.