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Syntheses of Some Norcholanylisoquinoline Derivatives
Author(s) -
Golander Yechiel,
Breuer Eli,
Sarel Shalom
Publication year - 1979
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19793120409
Subject(s) - chemistry , yield (engineering) , derivative (finance) , organic chemistry , stereochemistry , materials science , economics , financial economics , metallurgy
N ‐Phenethyl‐ and N ‐[2‐(3′,4′‐dimethoxyphenyl)ethyl]amides 5‐8 of cholanic acid and 3α‐acetoxy‐cholanic acid were subjected to the Bischler‐Napieralski reaction to yield the respective 3′,4′‐di‐hydroisoquinolines, 9‐12. Reaction of 5 also yielded N,N ‐bis(phenethyl)cholanamidine 13 . The 3′,4′‐dihydroisoquinoline 11 was converted to the tetrahydro derivative 14 and to the aromatic compounds 15 and 16 .