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The Characterization of the Silver Compounds of Some Sulfanilamide Derivatives
Author(s) -
Bult Auke,
Klasen Huub B.
Publication year - 1978
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19783111009
Subject(s) - chemistry , sulfamerazine , sulfanilamide , sulfadimethoxine , picrate , sulfonamide , silver sulfadiazine , sulfisoxazole , sulfadiazine , medicinal chemistry , inorganic chemistry , organic chemistry , ion , chromatography , biochemistry , antibiotics , wound healing , immunology , tetracycline , biology
The structures of 1: 1 compounds of silver with twelve sulfanilamide derivatives are studied. In the compounds with sulfadimethoxine and sulfafenazole the silver ion is coordinated to the deprotonated amido nitrogen (amido‐Ag structure). In the compounds with sulfadimidine, sulfamerazine, sulfamethoxazole, sulfamethoxydiazine, sulfamethoxypyrazine, sulfamethoxypyridazine, sulfamethylthiadiazole, sulfamoxol, sulfisomidine and sulfisoxazole the silver ion is coordinated to the nitrogen which is attached to the atom in the substituent (imido‐Ag structure). In the compounds with sulfamerazine and sulfamethoxypyrazine the aromatic amine group is probably involved in coordination. The findings are discussed in relation to the results of a preliminary study on sulfadiazine silver. This silver compound is exceptional among the silver sulfanilamides because of its amido‐Ag structure. There are indications that sulfadiazine silver has a high formation constant as compared with the other silver sulfanilamides.