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Synthesis and Central Nervous System Depression Properties of Disubstituted Sydnones
Author(s) -
Ugarkar Bheemarao G.,
Badami Bharati V.,
Puranik Gurubasav S.,
Bhat K. G. Subramanya
Publication year - 1978
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19783110205
Subject(s) - sydnone , depression (economics) , ring (chemistry) , central nervous system , chemistry , stereochemistry , action (physics) , medicine , organic chemistry , physics , quantum mechanics , economics , macroeconomics
A number of unknown disubstituted 3‐phenylsydnones are synthesized and subjected for preliminary screening. Methyl, bromo and chloro groups in the phenyl ring of 3‐tolylsydnones enhance the CNS depression action while the methyl group in the 4‐position of the sydnone ring does not add to the CNS depression action shown by the original sydnone.