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Pathway and regulation of JHIII‐bisepoxide biosynthesis in adult Drosophila melanogaster corpus allatum
Author(s) -
Moshitzky Pnina,
Applebaum Shalom W.
Publication year - 1995
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.940300211
Subject(s) - corpus allatum , drosophila melanogaster , biosynthesis , endogeny , biology , melanogaster , limiting , in vitro , biochemistry , microbiology and biotechnology , endocrinology , medicine , enzyme , juvenile hormone , gene , hormone , mechanical engineering , engineering
Abstract Adult female Drosophila melanogaster corpus allatum (CA) synthesize JHB 3 from endogenous and exogenous precursors in vitro. We present evidence supporting the thesis that biosynthesis proceeds from precursor FA via initial epoxidation and terminal methylation on the basis of the following: (1) Methyl farnesoate is not epoxidized to JHIII or JHB 3 ; (2) Authentic JHIII is not epoxidized to JHB 3 ; and (3) FABE is markedly metabolized to JHB 3 . Cerebral allatostatic factors act at some stage subsequent to FA and this precursor is not normally rate‐limiting. Additionally, neural inhibition from the brain acts at some biosynthetic step prior to FA. © 1995 Wiley‐Liss, Inc.