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Neosurugatoxin blocks an α‐bungarotoxin‐sensitive neuronal nicotinic acetylcholine receptor
Author(s) -
Bai Donglin,
Sattelle David B.
Publication year - 1993
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.940230403
Subject(s) - periplaneta , cockroach , acetylcholine receptor , neurotoxin , nicotinic agonist , american cockroach , biology , nicotinic acetylcholine receptor , nicotine , acetylcholine , blattidae , receptor , nicotinic antagonist , pharmacology , biochemistry , neuroscience , ecology
Neosurugatoxin (NSTX), a neurotoxin isolated from the Japanese ivory mollusc Babylonia japonica , is a potent neuronal nicotinic acetylcholine receptor (nAChR) antagonist. Hitherto, NSTX has been found to block only neuronal nAChRs that are insensitive to α‐Bgt. Here, we report for the first time that NSTX blocks an α‐Bgt‐sensitive nAChR on an identified insect motor neurone. Bath‐applied NSTX at a concentration of 10 nM and above reversibly blocks the nicotine‐induced depolarizations recorded from the cockroach (Periplaneta americana) fast coxal depressor motor neurone (D f ) and is without effect on GABA‐induced responses detected on the same cell. NSTX is among the most potent blockers tested to date on nAChRs of motor neurone D f . © 1993 Wiley‐Liss, Inc.