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Generation of superoxide anion radical by α‐terthienyl in the anal gills of mosquito larvae Aedes aegypti : A new aspect in α‐terthienyl phototoxicity
Author(s) -
Nivsarkar Manish,
Kumar G Pradeep,
Laloraya Malini,
Laloraya Manmohan M.
Publication year - 1992
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.940190405
Subject(s) - phototoxicity , aedes aegypti , superoxide , singlet oxygen , chemistry , photochemistry , biology , in vitro , biochemistry , larva , enzyme , botany , oxygen , organic chemistry
The present study documents that the secondary plant metabolites, especially α‐terthienyl, exert phototoxic action through inhibition of certain enzymes and generation of singlet oxygen. Some of the reports have emerged exhibiting involvement of free radical generation in vitro by α‐terthienyl. We provide evidence for the generation of a free radical viz., superoxide anion radical, by α‐terthienyl employing spin‐trapping techniques, probably due to the extension of the latter reaction. On the basis of this observation the phototoxic action of α‐terthienyl on Aedes aegypti larvae is explained. © 1992 Wiley‐Liss, Inc.