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Neuromodulator octopamine attenuates extrajunctional glutamate sensitivity in insect muscle
Author(s) -
Yamamoto Daisuke,
Ishikawa Sachiyo
Publication year - 1991
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.940180408
Subject(s) - octopamine (neurotransmitter) , biology , depolarization , forskolin , activator (genetics) , adenosine , glutamate receptor , biochemistry , mealworm , biophysics , medicine , endocrinology , receptor , botany , serotonin , larva
Octopamine was found to decrease extrajunctional, but not junctional glutamate responses, in mealworm neuromuscular preparations. This action of octopamine was mimicked by forskolin, 8‐(4‐chlorophenylthio)‐adenosine 3′:5′‐cyclic monophosphate (CPT‐cyclic AMP), and 8‐bromoguanosine 3′:5′‐cyclic monophosphate (8‐bromo‐cyclic GMP), but not by 1,2‐oleoylacetylglycerol (OAG), a protein kinase C activator. We suggest that the octopamine‐induced reduction in the glutamate sensitivity of extrajunctional membranes may enable the muscle to more closely follow its neuronal input by preventing a depolarization (and hence a conductance increase) due to the discharge of unsequestered transmitter molecules at nonsynaptic sites.