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Mode of action of diptericin A, a bactericidal peptide induced in the hemolymph of Phormia terranovae larvae
Author(s) -
Keppi Elisabeth,
Pugsley Anthony P.,
Lambert Jean,
Wicker Claude,
Dimarcq JeanLuc,
Hoffmann Jules A.,
Hoffmann Danièle
Publication year - 1989
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.940100306
Subject(s) - phormia regina , hemolymph , biology , bacteria , mode of action , larva , peptide , microbiology and biotechnology , residue (chemistry) , gram negative bacteria , calliphoridae , biochemistry , ecology , genetics , gene , escherichia coli
Diptericin A is a member of a multigenic family of antibacterial peptides that are synthesized by larvae of Phormia terranovae (Diptera) in response to a bacterial injection or to injury. The 82‐residue peptide is active only against a limited range of Gram‐negative bacteria. Data presented suggest that the primary action of diptericin A is on the cytoplasmic membrane of growing bacteria.