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Metabolism and excretion of acetylchromenes by the migratory grasshopper
Author(s) -
Isman Murray B.,
Proksch Peter,
Witte Ludger
Publication year - 1987
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.940060205
Subject(s) - metabolite , excretion , grasshopper , metabolism , biology , hydroxylation , acrididae , insect , urine , cuticle (hair) , toxicity , locust , arthropod cuticle , biochemistry , toxicology , orthoptera , botany , chemistry , ecology , anatomy , organic chemistry , enzyme
The extent of metabolism and excretion of three acetylchromenes (two toxic, one relatively nontoxic) were examined in adult migratory grasshoppers ( Melanoplus sanguinipes ) following topical administration. Both the total amount excreted (parent plus metabolites) and the proportion of parent compound in the excreta were inversely correlated with contact toxicity. Both toxic and nontoxic acetylchromenes are rapidly absorbed from the cuticle, with maximum excretion of parent and metabolite chromenes from 4 to 8 h posttreatment in each case. Much of the applied compounds (60–80%) apparently remains within the insect, and cannot be recovered by extraction of the insect. Metabolites formed result from simple oxidative and reductive transformations. For all of the compounds tested (including the allatocidin precocene II), the major mode of metabolism results from aliphatic hydroxylation of one of the geminal methyl groups on the chromene. No conjugated metabolites were found in the excreta.