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Evidence for a presynaptic action of chlordimeform at the insect neuromuscular junction
Author(s) -
Yamamoto Daisuke,
Washio Hiroshi,
Fukami JunIchi
Publication year - 1983
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.940010105
Subject(s) - excitatory postsynaptic potential , neuromuscular junction , postsynaptic potential , biology , neuromuscular transmission , extracellular , neurotransmission , mealworm , biophysics , calcium , neuroscience , inhibitory postsynaptic potential , endocrinology , biochemistry , medicine , receptor , botany , larva
The mechanism of action of chlordimeform on the mealworm nerve‐muscle preparation was studied with microelectrodes. Chlordimeform affected neither the mean amplitude nor the frequency of spontaneous miniature excitatory postsynaptic potentials. Extracellular focal recordings show that in the presence of 0.8 mM chlordimeform the presynaptic spike is almost unchanged, but the quantal content for evoked transmitter release is reduced. It is suggested that chlordimeform decreases the influx of calcium at the presynaptic terminal during the active phase of the nerve terminal action potential, thereby inhibiting evoked transmitter release.