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CncC/Maf‐mediated xenobiotic response pathway in insects
Author(s) -
Palli Subba Reddy
Publication year - 2020
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.21674
Subject(s) - biology , cytochrome p450 , gene , atp binding cassette transporter , xenobiotic , transcription factor , monooxygenase , in silico , enzyme , biochemistry , glutathione , transporter , genetics , metabolic pathway , microbiology and biotechnology
Insects have evolved resistance to almost all insecticides developed for their control. Multiple mechanisms of resistance, including enhanced metabolism and excretion of insecticides, target‐site insensitivity, reduced penetration of insecticides, and avoidance behavior, have been reported. The genes coding for proteins involved in resistance have been identified in numerous insects. The enzymes and transporters required for all three phases of insecticide metabolism and excretion including cytochrome P450 monooxygenases, glutathione S‐transferases, UDP‐glucuronosyltransferases, carboxylesterases, and ATP‐binding cassette transmembrane transporters have been identified. Recent research in multiple insect species identified CNC‐bZIP transcription factor superfamily members as regulators of genes coding for enzymes and transporters involved in insecticide metabolic resistance. The information on the pathway including reactive oxygen species, cap “n” collar isoform‐C, and its heterodimer partner, muscle aponeurosis fibromatosis transcription factors involved in overexpression of enzymes and transporters involved insecticide resistance will be summarized.