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Characterization of two novel antimicrobial peptides from the cuticular extracts of the ant Trichomyrmex criniceps (Mayr), (Hymenoptera: Formicidae)
Author(s) -
Bhagavathula Nagachaitanya,
Meedidoddi Venkateshwarlu,
Bourque Simon,
Vimaladevi Reshmy,
Kesavakurup Santoshkumar,
Selvadurai Dayanandan,
Shrivastava Sameer,
Krishnappa Chandrashekara
Publication year - 2017
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.21381
Subject(s) - antimicrobial , antimicrobial peptides , peptide , hymenoptera , biology , ant , antibacterial peptide , biochemistry , molecular mass , microbiology and biotechnology , bacteria , antibacterial activity , botany , ecology , enzyme , genetics
Antimicrobial peptides (AMPs) from cuticular extracts of worker ants of Trichomyrmex criniceps (Mayr, Hymenoptera: Formicidae) were isolated and evaluated for their antimicrobial activity. Eight peptides ranging in mass from 804.42 to 1541.04 Da were characterized using a combination of analytical and bioinformatics approach. All the eight peptides were novel with no similarity to any of the AMPs archived in the Antimicrobial Peptide Database. Two of the eight novel peptides, the smallest and the largest by mass were named Crinicepsin‐1 and Crinicepsin‐2 and were chemically synthesized by solid phase peptide synthesis. The two synthetic peptides had antibacterial and weak hemolytic activity.