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Bombyx mori prothoracicostatic peptide inhibits ecdysteroidogenesis in vivo
Author(s) -
Liu Xin,
Tanaka Yoshiaki,
Song Qisheng,
Xu Bujin,
Hua Yuejin
Publication year - 2004
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/arch.20005
Subject(s) - bombyx mori , biology , in vivo , peptide , microbiology and biotechnology , biochemistry , computational biology , genetics , gene
Abstract Bombyx prothoracicostatic peptide ( Bom ‐PTSP) is a brain neuropeptide that has recently been reported to have in vitro inhibitory activity to prothoracicotropic hormone (PTTH)‐stimulated ecdysteroid biosynthesis in the prothoracic gland of the silkworm, Bombyx mori . In the present report, Bom ‐PTSP has been shown to significantly decrease hemolymph ecdysteroid titer in the fifth instar larvae when Bom ‐PTSP was injected into the fifth instar day 8 silkworm larvae, resulting in significant delay in spinning behavior. This is the first evidence that Bom ‐PTSP inhibits in vivo ecdysteroidogenesis in the silkworm. Arch. Insect Biochem. Physiol. 56:155–161, 2004. © 2004 Wiley‐Liss, Inc.