Open AccessEGF‐dependent and independent activation of MAP kinase during Drosophila oogenesis
Author(s) -
Dammai Vincent,
Hsu Tien
Publication year - 2003
Publication title -
the anatomical record part a: discoveries in molecular, cellular, and evolutionary biology
Language(s) - English
Resource type - Journals
eISSN - 1552-4892
pISSN - 1552-4884
DOI - 10.1002/ar.a.10037
Subject(s) - microbiology and biotechnology , map kinase kinase kinase , mapk7 , ask1 , biology , mitogen activated protein kinase , receptor tyrosine kinase , signal transduction , kinase , mitogen activated protein kinase kinase , protein kinase a
Receptor tyrosine kinase (RTK) signaling is involved in multiple cell fate determination during Drosophila oogenesis. To address the problem of signaling specificity, we sought to systematically document the expression pattern of activated MAP kinase, the downstream effector of RTK signaling. We show that MAP kinase is activated in some of the cell types in which Drosophila EGF receptor signaling is known to function. MAP kinase activation is also associated with many cell migration events. Finally, MAP kinase is activated by heat stress without altering follicle cell fates. The implications of these findings are discussed. Anat Rec Part A 272A:377–382, 2003. © 2003 Wiley‐Liss, Inc.