Open AccessProminent expression of lysyl oxidase during mouse embryonic cardiovascular development
Author(s) -
Tsuda Takeshi,
Pan TeCheng,
Evangelisti Lucia,
Chu MonLi
Publication year - 2003
Publication title -
the anatomical record part a: discoveries in molecular, cellular, and evolutionary biology
Language(s) - English
Resource type - Journals
eISSN - 1552-4892
pISSN - 1552-4884
DOI - 10.1002/ar.a.10002
Subject(s) - lysyl oxidase , elastin , in situ hybridization , embryonic stem cell , messenger rna , biology , embryogenesis , microbiology and biotechnology , heart development , anatomy , embryo , gene , extracellular matrix , biochemistry , genetics
Abstract By mRNA differential display in mouse hearts, lysyl oxidase ( Lox ), a key enzyme catalyzing cross‐links in elastin and collagens, was found to be up‐regulated between embryonic days 11 (E11) and 13 (E13). This was confirmed by semiquantitative RT‐PCR. We analyzed its spatio‐temporal expression pattern by in situ hybridization in regard to the development of myocardial cells, endocardial cushion tissue, aortic arch vessels, and epicardium. Anat Rec Part A 270A:93–96, 2003. © 2003 Wiley‐Liss, Inc.