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RETRACTED: MiR‐93 blocks cell cycle progression and promotes apoptosis in uterine leiomyoma cells by targeting CCND1
Author(s) -
Zhang Donghong,
Liu Enling,
Tian Wei,
Zhang Zhiyong,
Wang Liqun,
Li Jun
Publication year - 2020
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.24308
Subject(s) - apoptosis , microrna , cyclin d1 , leiomyoma , cancer research , uterine leiomyoma , cell cycle , viability assay , cell cycle checkpoint , cell cycle progression , biology , cell growth , microbiology and biotechnology , medicine , gene , pathology , genetics
Uterine leiomyoma (UL) is the most common type of benign tumor in the women's reproductive system. A number of genes has been found to play an important role in the initiation and progression of UL, including miRNAs. In this study, our results exhibited that miR‐93, a member of mir‐106b‐25 cluster, significantly reduced the cell viability, promoted cell cycle arrest, caused apoptosis, and inhibited migration in UL cells ( p < .01). Moreover, our results have provided experimental evidence that miR‐93 regulated the biological functions of UL cells by targeting CCND1.