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Mesenchymal Stem Cell (MSC)‐Derived Extracellular Vesicles: Potential Therapeutics as MSC Trophic Mediators in Regenerative Medicine
Author(s) -
Yuan Qiling,
Zhang Yingang,
Chen Qian
Publication year - 2020
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.24186
Subject(s) - microvesicles , mesenchymal stem cell , microbiology and biotechnology , regenerative medicine , biology , progenitor cell , regeneration (biology) , microrna , secretion , extracellular vesicles , stem cell , induced pluripotent stem cell , embryonic stem cell , gene , biochemistry
Mesenchymal stem cells (MSCs) are pluripotent progenitor cells with the capabilities of self‐renewing, differentiating into multiple lineages, and achieving trophic effects during tissue repair. MSCs can secrete extracellular vesicles (EVs) including exosomes and microvesicles, which mediate their trophic effects on other cells. Carrying a variety of intracellular molecules of MSCs including lipids, proteins, RNA (mRNA and noncoding RNA), and DNA, EVs deliver them into other cells to regulate tissue regeneration process. The therapeutic effects of MSC‐derived EVs have been observed in a number of animal disease models. In this review, we focus on the current state and future directions of MSC‐derived EVs in regenerative medicine. Anat Rec, 2019. © 2019 Wiley Periodicals, Inc.