Mesenchymal Stem Cell (MSC)‐Derived Extracellular Vesicles: Potential Therapeutics as MSC Trophic Mediators in Regenerative Medicine | Zendy

Yuan Qiling | Zendy; Zhang Yingang | Zendy; Chen Qian | Zendy

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Mesenchymal Stem Cell (MSC)‐Derived Extracellular Vesicles: Potential Therapeutics as MSC Trophic Mediators in Regenerative Medicine

Author(s) -

Yuan Qiling,

Zhang Yingang,

Chen Qian

Publication year - 2020

Publication title -

the anatomical record

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.678

H-Index - 62

eISSN - 1932-8494

pISSN - 1932-8486

DOI - 10.1002/ar.24186

Subject(s) - microvesicles , mesenchymal stem cell , regenerative medicine , microbiology and biotechnology , biology , regeneration (biology) , progenitor cell , stem cell , microrna , secretion , induced pluripotent stem cell , embryonic stem cell , gene , biochemistry

Mesenchymal stem cells (MSCs) are pluripotent progenitor cells with the capabilities of self‐renewing, differentiating into multiple lineages, and achieving trophic effects during tissue repair. MSCs can secrete extracellular vesicles (EVs) including exosomes and microvesicles, which mediate their trophic effects on other cells. Carrying a variety of intracellular molecules of MSCs including lipids, proteins, RNA (mRNA and noncoding RNA), and DNA, EVs deliver them into other cells to regulate tissue regeneration process. The therapeutic effects of MSC‐derived EVs have been observed in a number of animal disease models. In this review, we focus on the current state and future directions of MSC‐derived EVs in regenerative medicine. Anat Rec, 2019. © 2019 Wiley Periodicals, Inc.

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