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4,4′‐Diaponeurosporene‐Producing Bacillus subtilis Promotes the Development of the Mucosal Immune System of the Piglet Gut
Author(s) -
Jing Yuchao,
Liu Haofei,
Xu Wenwen,
Yang Qian
Publication year - 2019
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.24102
Subject(s) - immune system , intraepithelial lymphocyte , biology , lamina propria , microbiology and biotechnology , ileum , cd8 , mucosal immunity , immunology , immunity , bacillus subtilis , crypt , enterocyte , small intestine , epithelium , bacteria , endocrinology , genetics
Gut mucosal immune responses are known to act as the first line of defense against invasion of pathogenic microorganisms. Piglets have an incompletely developed gut mucosal immune system, making them sensitive to intestinal infections. Promoting the development of the mucosal immune system will increase the pathogen resistance of piglets. The aim of the present study was to investigate the effect of carotenoid (4,4′‐diaponeurosporene)‐producing Bacillus subtilis ( B.s ‐Dia) on intestinal mucosal immunity in piglets. We showed that oral administration to piglets of B.s ‐Dia remarkably improved the development of Peyer's patches (PPs) ( P < 0.01), and increased villus height ( P < 0.01) and colon crypt depth ( P < 0.01). In addition, B.s ‐Dia also increased the number of intraepithelial lymphocytes ( P < 0.01), while Bacillus subtilis ( B.s ) had no significant influence on it ( P > 0.05). Moreover, B.s ‐Dia also increased the number of SIgA + cells ( P < 0.01). Oral administration of either B.s or B.s ‐Dia increased the number of CD4 + and CD8 + cells in ileum lamina propria ( P < 0.01). These results indicate that B.s ‐Dia contributes to a higher extent to porcine mucosal immune system development than B.s , and might serve as an immunopotentiator candidate. Anat Rec, 302:1800–1807, 2019. © 2019 American Association for Anatomy