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Role of MicroRNAs in the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease
Author(s) -
Zhang Cheng,
Wang Ping,
Li Yongqiang,
Huang Changxin,
Ni Wei,
Chen Yidan,
Shi Junping,
Chen Gongying,
Hu Xiangrong,
Ye Meng,
Duan Shiwei,
Wang Kaifeng
Publication year - 2019
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.23954
Subject(s) - nonalcoholic fatty liver disease , hepatocellular carcinoma , cirrhosis , insulin resistance , microrna , fatty liver , cancer research , medicine , pathogenesis , oxidative stress , lipid metabolism , disease , malignancy , liver disease , biology , insulin , gene , biochemistry
Hepatocellular carcinoma (HCC) is a prevalent liver malignancy that can be developed from nonalcoholic fatty liver disease (NAFLD). Numerous pathophysiological alterations, including insulin resistance, specific cytokine release, oxidative stress, and mitochondrial damage, are involved in the transition of NAFLD to cirrhosis and HCC. MicroRNAs, as post‐transcriptional modulators, play a critical role in the pathogenesis of NAFLD‐related HCC by regulating lipid metabolism, glucose homeostasis, cell proliferation, apoptosis, migration, and differentiation. This review summarizes the current progress of microRNAs in the risk and prognosis of NAFLD‐related HCC. Anat Rec, 302:193–200, 2019. © 2018 Wiley Periodicals, Inc.