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Generation and Biological Characteristics of a Mouse Model of Breast Cancer that Copresents with Diabetes Mellitus
Author(s) -
Li Mengshi,
Cao Jinghua,
He Yajun,
Zhou Zijun,
He Xiaodong,
Zhang QianQian,
Wang LiJing,
Qi CuiLing
Publication year - 2019
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.23945
Subject(s) - breast cancer , diabetes mellitus , medicine , cancer , metastasis , oncology , ca15 3 , cancer research , endocrinology
ABSTRACT Both diabetes and breast cancer are common diseases worldwide, and diabetes is also linked to higher rates of breast cancer. Epidemiological data also indicate that diabetes may be one of the risk factors for breast cancer. However, the effect of diabetes on breast cancer progression in vivo is rarely reported. We established an ideal animal model of breast cancer using transgenic MMTV‐PyMT mice, which spontaneously developed breast cancer. In this model, the animals copresented with diabetes mellitus, which allowed us to study the effect of high glucose on breast cancer. Compared with MMTV‐PyMT mice without diabetes, MMTV‐PyMT mice with diabetes developed heavier tumors and exhibited greater tumor volumes. Furthermore, high glucose promoted the invasiveness and metastasis of breast cancer in MMTV‐PyMT mice. This breast cancer model in which mice copresented with diabetes provides a useful tool to study the effect of diabetes on breast cancer. Anat Rec, 302:269–277, 2019. © 2018 Wiley Periodicals, Inc.