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Antiarthritic Effects of Sorafenib in Rats with Adjuvant‐Induced Arthritis
Author(s) -
Wang ZhenZhen,
Liu Fei,
Gong YongFang,
Huang TianYu,
Zhang XiaoMing,
Huang XueYing
Publication year - 2018
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.23856
Subject(s) - medicine , rheumatoid arthritis , sorafenib , tumor necrosis factor alpha , arthritis , synovial membrane , vascular endothelial growth factor , intradermal injection , inflammation , endocrinology , pharmacology , immunology , vegf receptors , hepatocellular carcinoma
Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the synovial membrane of joints. In this study, we aimed to investigate whether sorafenib exerts antiarthritic effects on RA in vivo . Adjuvant arthritis (AA) was induced (day 0) in male Sprague–Dawley rats by intradermal injection of 0.1 mL of complete Freund's complete adjuvant into the left hind paw. Sorafenib (10, 20, or 40 mg/kg/day) was administered intragastrically from day 10 to 24. Body weight, paw volume, synovial inflammation, and tumor necrosis factor alpha (TNF‐α), interleukin‐1β (IL‐1β), IL‐10, and IL‐17 serum levels were detected. In addition, microvascular density (MVD) and the expression of vascular endothelial growth factor receptor 2 (VEGFR‐2) and fibroblast growth factor receptor 1 (FGFR‐1) in synovial tissues were analyzed. Our data revealed that sorafenib administration led to significant body weight gain in AA rats but suppressed paw swelling, synovial hyperplasia, and inflammatory infiltration. Furthermore, it decreased TNF‐α, IL‐1β, and IL‐17 serum levels and upregulated IL‐10. MVD and VEGFR‐2 and FGFR‐1 expression in synovial tissues were significantly reduced. Thus, this study shows that sorafenib exerts anti‐arthritic effects in AA rats and therefore has potential in RA treatment. Anat Rec, 301:1519–1526, 2018. © 2018 Wiley Periodicals, Inc.