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Myricetin Induces Protective Autophagy by Inhibiting the Phosphorylation of mTOR in HepG2 Cells
Author(s) -
Cao Jianping,
Chen Hanwen,
Lu Wei,
Wu Yihua,
Wu Xia,
Xia Dajing,
Zhu Jiang
Publication year - 2018
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.23754
Subject(s) - myricetin , autophagy , pi3k/akt/mtor pathway , cancer cell , cancer , chemistry , pharmacology , context (archaeology) , carcinogenesis , flavonoid , apoptosis , cancer research , biology , microbiology and biotechnology , biochemistry , medicine , antioxidant , kaempferol , paleontology
ABSTRACT Myricetin, a natural flavonoid present in a variety of fruits and vegetables, has been studied as a promising cancer chemopreventive agent in many cancer models. It has been reported that myricetin could inhibit tumor promotion by inducing cell cycle arrest and promoting apoptotic cell death. At present, autophagy is considered to be closely associated with cancer, functioning as either an anti‐cancer or pro‐cancer mechanism depending on the cancer stage. Till date, the role of myricetin in regulating autophagy has not been reported. In this study, we found that myricetin can induce autophagy by inhibiting mTOR activation in HepG2 cells. Our findings thus provide evidence for further research and application of myricetin as a potential cancer therapeutic agent. Anat Rec, 301:786–795, 2018. © 2017 Wiley Periodicals, Inc.