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Functional Tissue Engineering of the Liver and Islets
Author(s) -
Ohashi Kazuo,
Okano Teruo
Publication year - 2014
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.22810
Subject(s) - islet , in vivo , medicine , diabetes mellitus , liver tissue , insulin , bioinformatics , cancer research , biology , endocrinology , microbiology and biotechnology
Cell‐based therapies by using hepatocytes and islets have recently been evaluated as a new therapeutic modality for patients with many forms of liver diseases and insulin‐deficient diabetes mellitus. In most of the recently conducted clinical trials, cells have been delivered into liver vasculatures by infusing them through the portal circulation. More recently, tissue engineering–based approaches have spurred significant interests, using hepatocytes and islets in which small but functional new tissues would be created in vivo . Under circumstances in which a higher level of cell engraftment could be obtained, these approaches could provide therapeutic effects. Considerable efforts have been given to sustaining engineered tissues and maintaining their therapeutic effects. This review highlights several strategies that can achieve a higher level of cell survival for creating new functional liver and islet tissues. Anat Rec, 297:73–82. 2014. © 2013 Wiley Periodicals, Inc.