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Integration of Autophagy and Anoikis Resistance in Solid Tumors
Author(s) -
Yang Jie,
Zheng Zhichao,
Yan Xiaojie,
Li Xia,
Liu Zhe,
Ma Zhenyi
Publication year - 2013
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.22769
Subject(s) - anoikis , autophagy , context (archaeology) , microbiology and biotechnology , carcinogenesis , metastasis , cancer research , biology , extracellular matrix , apoptosis , programmed cell death , chemistry , neuroscience , cancer , biochemistry , genetics , paleontology
Macroautophagy or autophagy is a lysosome‐dependent process in which enzymatic degradation and recycling of cytosolic components occurred due to stressful conditions. This cellular arrangement imparts anoikis resistance in solid tumors. Anoikis, a special form of apoptosis occurring when cells detach from the extracellular matrix, is a critical mechanism in maintaining tissue homeostasis and development. Anoikis resistance facilitates tumorigenesis and metastasis. However, the complexity of the role of autophagy in tumor is underscored by evidence that autophagy can function as both a pro‐survival or pro‐death depending on the context and the stimuli, which are likely exploitable for tumor therapy. This review focuses on recent progress in understanding anoikis resistance and autophagy signaling, paying particular attention to its relevance in solid tumor metastasis. Anat Rec, 296:1501–1508, 2013. © 2013 Wiley Periodicals, Inc.