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Serglycin in Health and Diseases
Author(s) -
Scully Olivia J.,
Chua PeiJou,
Harve Karthik S.,
Bay BoonHuat,
Yip George W.
Publication year - 2012
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.22536
Subject(s) - hemostasis , apoptosis , pathological , microbiology and biotechnology , platelet , biology , medicine , cancer research , immunology , pathology , genetics
Serglycin is a multifunctional molecule and one of the first proteoglycans to be cloned. In this manuscript, we examine the physiological roles of serglycin in immunity, hemostasis, cell growth, apoptosis, and reproduction. In addition, we review recent studies on the involvement of serglycin in various pathological conditions, including cancer, inflammatory diseases, and platelet disorders. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.