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Cortical Bone Response to the Presence of Load‐Bearing Percutaneous Osseointegrated Prostheses
Author(s) -
Jeyapalina Sujee,
Beck James Peter,
Bachus Kent N.,
Bloebaum Roy D.
Publication year - 2012
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.22533
Subject(s) - periprosthetic , osseointegration , medicine , cortical bone , implant , percutaneous , apposition , surgery , dentistry , anatomy , arthroplasty
Although the current percutaneous osseointegrated (OI) prosthetic attachment systems are novel clinical treatments for patients with limb loss, there have only been limited translational studies undertaken to date. To bridge this knowledge gap, from a larger study group of 86 animals that were implanted with a novel percutaneous OI implant construct, 33 sheep were randomly selected from the 0‐, 3‐, 6‐, 9‐ and 12‐month groups for histomorphometric analyses of periprosthetic cortical bone tissue. At necropsy, implanted and nonimplanted limbs were harvested and processed for the evaluation of cortical bone porosity and mineral apposition rate (MAR). The data showed a maximum increase in bone porosity within the first 3 months following implantation and then a progressive reduction in porosity to the baseline steady‐state (“Time 0”) value by 12 months. The data further verified that the MAR increased during the first 6 months of implantation, reaching a plateau between 6 and 9 months, followed by a progressive decline to the baseline steady state. It was concluded that clinical load bearing and falls precautions, taken during the first 3–6 months following percutaneous OI device implantation surgery, could greatly limit bone fractures during this vulnerable time of increasing cortical bone porosity. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.