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Mitochondrial Division in Rat Cardiomyocytes: An Electron Microscope Study
Author(s) -
Fujioka Hisashi,
Tandler Bernard,
Hoppel Charles L.
Publication year - 2012
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.22523
Subject(s) - mitochondrion , organelle , endoplasmic reticulum , division (mathematics) , crista , electron microscope , limiting , biophysics , inner membrane , microbiology and biotechnology , cell division , membrane , chemistry , inner mitochondrial membrane , biology , anatomy , cell , physics , biochemistry , optics , engineering , mechanical engineering , arithmetic , mathematics
In cardiomyocytes of rats, two distinct mitochondrial division processes are in operation. The predominant process involves extension of a single crista until it spans the full width of a mitochondrion. Ingrowth of the outer membrane ultimately results in scission. The second division process involves “pinching,” in which narrowing of the organelle at specific surface locations leads to its attenuation. When limiting membranes from opposite sides meet, mitochondrial fission ensues. When pinching is the operative mode, elements of sarcoplasmic reticulum always are associated with the membrane constrictions. The nuclear control mechanisms that determine which modality of mitochondrial division will prevail are unknown. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.