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Chronological and Morphological Study of Heart Development in the Rat
Author(s) -
Marcela Salazar García,
Cristina Revilla Monsalve María,
Angel Palomino Garibay Miguel,
Manuel Arteaga Martínez,
Sofía DíazCintra,
Patricia De La RosaSantander,
Bladimir RoqueRamírez,
Concepción Sánchez Gómez
Publication year - 2012
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.22508
Subject(s) - embryo , embryology , heart development , morphogenesis , biology , teratology , embryogenesis , embryonic heart , model organism , embryonic stem cell , developmental biology , in vivo , atrioventricular cushions , physiology , anatomy , pathology , microbiology and biotechnology , fetus , medicine , heart disease , pregnancy , genetics , gene
Adult and embryonic laboratory rats have been used as a mammalian model organism in biomedical research, descriptive and experimental cardiac embryology, and experimental teratology. There have been, however, considerable variations and discrepancies concerning the developmental staging of the rat embryo in the reported literature, which have resulted in several controversies and inconsistencies. Therefore, we carried out a careful anatomical and histological study of rat cardiac morphogenesis from the premorphogenetic period to the mature heart in a newborn pup. A correlation between the chronology and morphological features of the heart and embryo or newborn was made. We provide a simple and comprehensive guide relating the developmental timing and fate of the embryonic components of the heart and their morphological changes in the rat based on in vivo labeling studies in the chick. We also compare the timing of heart development in rats, humans, and mice. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.