Premium
Morphological Development and Expression of Neurotrophin Receptors in the Laryngeal Sensory Corpuscles
Author(s) -
Yamamoto Yoshio,
Hashiguchi Momo,
YamaguchiYamada Misuzu
Publication year - 2011
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.21344
Subject(s) - tropomyosin receptor kinase a , tropomyosin receptor kinase b , neurotrophin , tropomyosin receptor kinase c , biology , low affinity nerve growth factor receptor , sensory system , nerve growth factor , taste bud , free nerve ending , neuroscience , trk receptor , neurotrophin 3 , sensory receptor , anatomy , receptor , medicine , microbiology and biotechnology , endocrinology , taste , neurotrophic factors , brain derived neurotrophic factor , biochemistry , platelet derived growth factor receptor , growth factor
Abstract Morphological development of sensory structures in the laryngeal mucosa of postnatal rats was observed by use of immunohistochemistry for protein gene‐product 9.5 (PGP9.5). Moreover, expression changes of high affinity neurotrophin receptors, TrkA, TrkB and TrkC, and low affinity neurotrophin receptor p75 NTR were examined to elucidate the relationship to morphogenesis. Intraepithelial nerve endings and parent axons of the laminar endings with immunoreactivity for PGP9.5 have already appeared in the rat on embryonic day 18 (E18) as well as solitary chemoreceptor cells in the glottic cleft. According to neurotrophin receptors, TrkA immunoreactivity were observed on and after postnatal week 3 (3W) in the nervous sensory structures, that is, free nerve endings, laminar endings and sub‐ and intragemmal plexuses of the taste buds. In the laminar endings, TrkC immunoreactivity was also observed on and after 3W. According to the laryngeal sensory cells, the solitary chemoreceptor cells were immunoreactive to TrkA, TrkB, and TrkC on and after postnatal day 3 (P3). In the taste buds in arytenoid region, taste cells were immunoreactive for TrkA, TrkB, and TrkC on and after 3W, P14, and 3W, respectively. Immunoreactivity for p75 NTR was observed on the surface of taste cells on and after P9. The results of the present study suggest that sensory structures in the laryngeal mucosa were developed on perinatal days to involve respiratory reflex, and that neurotrophin receptors may take part in the regulation and maintenance of sensory structures. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.