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Age‐Related Changes of the Oligodendrocytes in Rat Subcortical White Matter
Author(s) -
Chen Lin,
Lu Wei,
Yang Zhengwei,
Yang Shu,
Li Chen,
Shi Xiaoyan,
Tang Yong
Publication year - 2011
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.21332
Subject(s) - white matter , oligodendrocyte , myelin , endocrinology , medicine , biology , stereology , central nervous system , magnetic resonance imaging , radiology
The age‐related changes, of the oligodendrocytes in rat subcortical white matter, were investigated in this study. The oligodendrocytes in subcortical white matter were labeled with anti‐2′,3′‐cyclic nucleotide 3′‐phosphodiesterase antibody (anti‐CNPase antibody, a specific marker of oligodendrocytes). The total number of CNPase + cells was estimated with an unbiased stereological technique, the optical fractionator. In this study, we found that the total number of CNPase + cells in the young male rats and aged male rats was 14.4 ± 1.2 × 10 6 and 9.0 ± 1.0 × 10 6 , respectively. The total number of the CNPase + cells in the subcortical white matter of aged rats was significantly decreased by 37.5% when compared to young male rats. This study demonstrated that there was an aged‐related decrease of the oligodendrocytes in subcortical white matter. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.